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CPET Core Lab

Cardiopulmonary exercise testing (CPET) is a noninvasive, integrative test of the whole body exercise response and is considered the gold standard in integrated performance measures. BCRI provides a central facility with hands on experience in CPET informed by years of clinical excellence and research in the field.

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Cardio-Pulmonary Exercise Testing (CPET)

Our specialized team of cardiologists, intern-ists and residents has a high level of exper-tise in performing and reading CPET. They are trained according to international stand-ards and are actively shaping the future of CPET within the international CPET com-munity.


Our CPET Core Lab is equipped with state-of-the-art technology. We provide the full range of CPET:

  • support
  • hands on training
  • theoretical teaching
  • consultation for the planning of experi-mental designs and challenges
  • site visits
  • (remote) equipment calibration and certifi-cation
  • enhancing site-performance
  • establishing uniformity and harmonization in a variety of CPET setups
  • assisting with tests
  • data management, handling and pro-cessing via a cloud based web service
  • normal-subject validations
  • clinical care validations
  • quality control & assurance
  • centralized test reading
  • timely results
  • Clinical judgment

We host an easy-to-use, easily accessible web based system to exchange CPET tests, perform centralized reading and provide feedback and within 48 hours.

Treadmill and cyclic ergometer challenges are fully supported; other CPET applications can be implemented as required.

Our state-of-the art CPET Laboratory not only provides diagnostic services within the Clinical Study Center (CRU) at Charité, Campus Virchow, Berlin, Germany. We also act as a globally active CPET Core Laboratory for cohort studies, registries, observational studies and interventional multicenter clinical trials for surrogate parameter outcome assessment.

Our CPET Laboratory and CPET Core Laboratory have an established track record of cutting edge research in a wide spectrum of patients with heart and lung disease.

We assist and advise sponsors and investigators on clinical cohort studies, registries, observational studies and clinical trials with regard to performance related assessment in clinical research.


  • 2 CPET Laboratories
  • Inovision: InnoCor + Hemondynamics Mod-ule
  • Cortex: MetaControl 3000
  • Resting Calorimetry
  • HP Cosmos: Treadmills (2x)
  • Ergoline: Ergometer (2x)
  • Semi-Supine Ergometer (1x)
  • Fujitsu PC Workstations
  • SAP Infrastructure / Archiving / Server
  • 1 CPET Core Laboratory
  • Full-range data interpretation Software
  • Apple Macintosh & Fujitsu PC Workstations
  • OwnCloud Front- and Backend
  • Archiving & Server Infrastructure

Ongoing Trials

Ex-DHF: Exercise Training in Diastolic Heart Failure (DFG)

Ex-VAD: Exercise Training in Patients with Left Ventricular Assist Devices (DZHK)

OptimEx: Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure (OptimEx-Clin) (NCT02078947)

Transition-CHF: Systolic Dysfunction to Congestive Heart Failure Cohort Study (TransitionCHF) (DZHK)

FIX-HF-5C: Evaluation of the Safety and Efficacy of the OPTIMIZER® System in Subjects with Moderate-to-Severe Heart Failure with EF between 25% and 45% (FIX-HF-5C) (NCT01381172)

Key Publications

Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial. Nolte K, Herrmann-Lingen C, Wachter R, Gelbrich G, Düngen HD, Duvinage A, Hoi-schen N, von Oehsen K, Schwarz S, Hasen-fuss G, Halle M, Pieske B, Edelmann F.Eur J Prev Cardiol. 2015 May;22(5):582-93. doi: 10.1177/2047487314526071. Epub 2014 Mar 13.

Effect of spironolactone on diastolic func-tion and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. Edelmann F, Wachter R, Schmidt AG, Kraigher-Krainer E, Colantonio C, Kamke W, Duvinage A, Stahrenberg R, Durstewitz K, Löffler M, Düngen HD, Tschöpe C, Herrmann-Lingen C, Halle M, Hasenfuss G, Gelbrich G, Pieske B; Aldo-DHF Investiga-tors. JAMA. 2013 Feb 27;309(8):781-91. doi: 10.1001/jama.2013.905.

Exercise training improves exercise capaci-ty and diastolic function in patients with heart failure with preserved ejection fraction: re-sults of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. Edelmann F1, Gelbrich G, Düngen HD, Fröh-ling S, Wachter R, Stahrenberg R, Binder L, Töpper A, Lashki DJ, Schwarz S, Herrmann-Lingen C, Löffler M, Hasenfuss G, Halle M, Pieske B. J Am Coll Cardiol. 2011 Oct 18;58(17):1780-91. doi: 10.1016/j.jacc.2011.06.054.


<link - mail><b>Univ.-Prof. Dr. med. Frank Edelmann</b></link>
<link - mail><b>Dr. med. Tobias Daniel Trippel</b></link>
Charité – Universitätsmedizin Berlin<br />Medizinische Klinik m. S. Kardiologie<br />Augustenburger Platz 1<br />D-13353 Berlin
t: +49 30 450 553 731 <br />f: +49 30 450 7 553 731<br /><br /><br />