Clinical Study Center
Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial.
Gheorghiade M, Greene SJ, Butler J, Filippatos G, Lam CS, Maggioni AP, Ponikowski P, Shah SJ, Solomon SD, Kraigher-Krainer E, Samano ET, Müller K, Roessig L, Pieske B; SOCRATES-REDUCED Investigators and Coordinators.
JAMA. 2015 Dec 1;314(21):2251-62. doi: 10.1001/jama.2015.15734.

Plasma mid-regional pro-adrenomedullin levels are inversely associated with anxiety but unrelated to depression: Results from the observational DIAST-CHF study in patients with cardiovascular risk factors.
Meyer T, Herrmann-Lingen C, Chavanon ML, Pieske B, Wachter R, Edelmann F.
Psychoneuroendocrinology. 2015 Dec;62:227-32. doi: 10.1016/j.psyneuen.2015.08.007. Epub 2015 Aug 13.

Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial.
Edelmann F, Holzendorf V, Wachter R, Nolte K, Schmidt AG, Kraigher-Krainer E, Duvinage A, Unkelbach I, Düngen HD, Tschöpe C, Herrmann-Lingen C, Halle M, Hasenfuss G, Gelbrich G, Stough WG, Pieske BM.
Eur J Heart Fail. 2015 Feb;17(2):214-23. doi: 10.1002/ejhf.203. Epub 2014 Nov 24.

Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.
Edelmann F, Wachter R, Schmidt AG, Kraigher-Krainer E, Colantonio C, Kamke W, Duvinage A, Stahrenberg R, Durstewitz K, Löffler M, Düngen HD, Tschöpe C, Herrmann-Lingen C, Halle M, Hasenfuss G, Gelbrich G, Pieske B; Aldo-DHF Investigators.

Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study.
Edelmann F, Gelbrich G, Düngen HD, Fröhling S, Wachter R, Stahrenberg R, Binder L, Töpper A, Lashki DJ, Schwarz S, Herrmann-Lingen C, Löffler M, Hasenfuss G, Halle M, Pieske B.
J Am Coll Cardiol. 2011 Oct 18;58(17):1780-91. doi: 10.1016/j.jacc.2011.06.054.

CPET Core Lab
Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial.
Nolte K, Herrmann-Lingen C, Wachter R, Gelbrich G, Düngen HD, Duvinage A, Hoischen N, von Oehsen K, Schwarz S, Hasenfuss G, Halle M, Pieske B, Edelmann F.
Eur J Prev Cardiol. 2015 May;22(5):582-93. doi: 10.1177/2047487314526071. Epub 2014 Mar 13.

Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.
Edelmann F, Wachter R, Schmidt AG, Kraigher-Krainer E, Colantonio C, Kamke W, Duvinage A, Stahrenberg R, Durstewitz K, Löffler M, Düngen HD, Tschöpe C, Herrmann-Lingen C, Halle M, Hasenfuss G, Gelbrich G, Pieske B; Aldo-DHF Investigators.
JAMA. 2013 Feb 27;309(8):781-91. doi: 10.1001/jama.2013.905.

Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study.
Edelmann F1, Gelbrich G, Düngen HD, Fröhling S, Wachter R, Stahrenberg R, Binder L, Töpper A, Lashki DJ, Schwarz S, Herrmann-Lingen C, Löffler M, Hasenfuss G, Halle M, Pieske B.
J Am Coll Cardiol. 2011 Oct 18;58(17):1780-91. doi: 10.1016/j.jacc.2011.06.054.

Echo Core Lab
Impaired systolic function by strain imaging in heart failure with preserved ejection fraction.
Kraigher-Krainer E, Shah AM, Gupta DK, et al.
J Am Coll Cardiol. 2014;63:447-56.
Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES).
Pieske B, Butler J, Filippatos G, Lam C, Maggioni AP, Ponikowski P, Shah S, Solomon S, Kraigher-Krainer E, et al.
Eur J Heart Fail. 2014;16:1026-38.

Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial.
Suchy C, Massen L, Rognmo O, Van Craenenbroeck EM, Beckers P, Kraigher-Krainer E, et al.
Eur J Prev Cardiol. 2014;21(2 Suppl):18-25.

Normal range and usefulness of right ventricular systolic strain to detect subtle right ventricular systolic abnormalities in patients with heart failure: a multicentre study.
Morris DA, Krisper M, Nakatani S, et al.
Eur Heart J Cardiovasc Imaging. 2016; doi:10.1093/ehjci/jew011.

Clinical relevance of left atrial strain to predict recurrence of atrial fibrillation after catheter ablation: a meta-analysis.
Ma XX, and Morris DA.
Echocardiography 2016; doi: 10.1111/echo.13184.

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial.
Gheorghiade M, Greene SJ, Butler J, Filippatos G, Lam CS, Maggioni AP, Ponikowski P, Shah SJ, Solomon SD, Kraigher-Krainer E, et al.
JAMA. 2015;314:2251-62.

Structural and functional cardiac analyses using modern and sensitive myocardial techniques in adult Pompe disease.
Morris DA, Blaschke D, Krebs A, Canaan-Kühl S, Plöckinger U, Knobloch G, Walter TC, Kühnle Y, Boldt LH, Kraigher-Krainer E, et al.
Int J Cardiovasc Imaging. 2015;31:947-56.

Clinical perspectives and evidence of diastolic stress test in heart failure with preserved ejection fraction.
Belyavskiy E, Morris DA, Kraigher-Krainer E, et al.
The Egyptian Heart Journal 2015; 67: 279–288.

Evaluation of a clinical decision support rule-set for medication adjustments in mHealth-based heart failure management.
Kropf M, Modre-Osprian R, Gruber K, et al.
Stud Health Technol Inform. 2015;212:81-7.

Normal values and clinical relevance of left atrial myocardial function analysed by speckle-tracking echocardiography: multicentre study.
Morris DA, Takeuchi M, Krisper M, et al.
Eur Heart J Cardiovasc Imaging. 2015;16:364-72.

MRI Core Lab
Potential Reduction of Interstitial Myocardial Fibrosis With Renal Denervation.
Doltra A, Messroghli D, Stawowy P, Hassel J, Gebker R, Leppänen O, Gräfe M, Schneeweis C, Schnackenburg B, Fleck E, Kelle S.
J Am Heart Assoc. 2014 Dec;3(6):e001353. doi: 10.1161/JAHA.114.001353.

Regional Coronary Endothelial Function Is Closely Related to Local Early Coronary Atherosclerosis in Patients With Mild Coronary Artery Disease.
Hays AG, Kelle S, Hirsch GA, Soleimanifard S, Yu J, Agarwal HK, Gerstenblith G, Schär M, Stuber M, Weiss RG.
Circ Cardiovasc Imaging. 2012 May 1;5(3):341-8. doi: 10.1161/CIRCIMAGING.

Prognostic Value of Myocardial Infarct Size and Contractile Reserve Using Magnetic Resonance Imaging.
Kelle S, Roes SD, Klein C, Kokocinski T, de Roos A, Fleck E, Bax JJ, Nagel E.
J Am Coll Cardiol. 2009 Nov 3;54(19):1770-7.

Coronary Artery Distensibility Assessed by 3.0 Tesla Coronary Magnetic Resonance Imaging in Subjects With and Without Coronary Artery Disease.
Kelle S, Hays AG, Hirsch GA, Gerstenblith G, Miller JM, Steinberg AM, Schär M, Texter JH, Wellnhofer E, Weiss RG, Stuber M.
Am J Cardiol. 2011 Aug 15;108(4):491-7.

Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial.
Mahfoud F, Urban D, Teller D, Linz D, Stawowy P, Hassel JH, Fries P, Dreysse S, Wellnhofer E, Schneider G, Buecker A, Schneeweis C, Doltra A, Schlaich MP, Esler MD, Fleck E, Böhm M, Kelle S.
Eur Heart J. 2014 Sep 1;35(33):2224-31b.

Delayed Contrast-Enhanced MRI of the Coronary Artery Wall in Takayasu Arteritis.
Schneeweis C1, Schnackenburg B, Stuber M, Berger A, Schneider U, Yu J, Gebker R, Weiss RG, Fleck E, Kelle S.
PLoS One. 2012;7(12):e50655.

A bi-center cardiovascular magnetic resonance prognosis study focusing on dobutamine wall motion and late gadolinium enhancement in 3,138 consecutive patients.
Kelle S, Nagel E, Voss A, Hofmann N, Gitsioudis G, Buss SJ, Chiribiri A, Wellnhofer E, Klein C, Schneeweis C, Egnell C, Vierecke J, Berger A, Giannitsis E, Fleck E, Katus HA, Korosoglou G.
J Am Coll Cardiol. 2013 Jun 4;61(22):2310-2.

Evaluation of Age-Related Interstitial Myocardial Fibrosis With Cardiac Magnetic Resonance Contrast-Enhanced T1 Mapping MESA (Multi-Ethnic Study of Atherosclerosis).
Liu CY, Liu YC, Wu C, Armstrong A, Volpe GJ, van der Geest RJ, Liu Y, Hundley WG, Gomes AS, Liu S, Nacif M, Bluemke DA, Lima JA.
J Am Coll Cardiol. 2013 Oct 1;62(14):1280-7.

Diagnostic Performance of Myocardial Perfusion MR at 3 T in Patients with Coronary Artery Disease.
Gebker R, Jahnke C, Paetsch I, Kelle S, Schnackenburg B, Fleck E, Nagel E.
Radiology. 2008 Apr;247(1):57-63.

T1 Mapping for Diffuse. Myocardial Fibrosis A Key Biomarker in Cardiac Disease?
Moon JC, Treibel TA, Schelbert EB.
J Am Coll Cardiol. 2013 Oct 1;62(14):1288-9.

The role of dobutamine stress cardiovascular magnetic resonance in the clinical management of patients with suspected and known coronary artery disease.
Gebker R, Jahnke C, Manka R, Hucko T, Schnackenburg B, Kelle S, Klein C, Fleck E, Paetsch I.
J Cardiovasc Magn Reson. 2011 Sep 12;13:46.

Human myocardium: single-breath-hold MR T1 mapping with high spatial resolution - reproducibility study.
Messroghli DR, Plein S, Higgins DM, Walters K, Jones TR, Ridgway JP, Sivananthan MU.
Radiology. 2006 Mar;238(3):1004-12.

Assessment of regional left ventricular function: accuracy and reproducibility of positioning standard short-axis sections in cardiac MR imaging.
Messroghli DR, Bainbridge GJ, Alfakih K, Jones TR, Plein S, Ridgway JP, Sivananthan MU.
Radiology. 2005 Apr;235(1):229-36.

Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping
Messroghli DR, Nordmeyer S, Dietrich T, Dirsch O, Kaschina E, Savvatis K, O h-Ici D, Klein C, Berger F, Kuehne T.
Circ Cardiovasc Imaging. 2011 Nov;4(6):636-40.

Preclinical MRI Center
Myocardial T1 maps reflect histological findings in acute and chronic stages of myocarditis in a rat model.
Jeuthe S, Wassilew K, O H-Ici D, da Silva TF, Münch F, Berger F, Kuehne T, Pieske B, Messroghli DR.
J Cardiovasc Magn Reson. 2016 Apr 16;18:19.

Closed-chest small animal model to study myocardial infarction in an MRI environment in real time.
O H-Ici D, Jeuthe S, Dietrich T, Berger F, Kuehne T, Kozerke S, Messroghli DR.
Int J Cardiovasc Imaging. 2015 Jan;31(1):115-21.

Mortality and morbidity in different immunization protocols for experimental autoimmune myocarditis in rats.
Schmerler P, Jeuthe S, O h-Ici D, Wassilew K, Lauer D, Kaschina E, Kintscher U, Müller S, Muench F, Kuehne T, Berger F, Unger T, Steckelings UM, *Paulis L, *Messroghli D.
Acta Physiol (Oxf). 2014;210(4):889-98.

Assessment of cardiac function and myocardial morphology using small animal Look-Locker inversion recovery (SALLI) MRI in rats.
Jeuthe S, O H-Ici D, Kemnitz U, Dietrich T, Schnackenburg B, Berger F, Kuehne T, Messroghli D.
J Vis Exp. 2013;(77).

Assessment of diffuse myocardial fibrosis in rats using small animal Look-Locker inversion recovery (SALLI) T1 mapping.
*Messroghli DR, *Nordmeyer S, Dietrich T, Dirsch O, Kaschina E, Savvatis K, O h-Ici D, Klein C, Berger F, Kuehne T. 
 

Circ Cardiovasc Imaging 2011;4(6):636-40.

Small Animal Look-Locker Inversion recovery (SALLI) for simultaneous generation of cardiac T1 maps, cine, and IR-prepared images at high heart rates: Initial experience. 

Messroghli DR, Nordmeyer S, Buehrer M, Kozerke S, Dietrich T, Kaschina E, Hucko T, Berger F, Klein C, Kuehne T. 

Radiology 2011; 261(1):258-265.

Trial Site and Early Phase Unit
Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure.
Greene SJ, Sabbah HN, Butler J, Voors AA, Albrecht-Küpper BE, Düngen HD, Dinh W, Gheorghiade M.
Heart Fail Rev. 2016 Jan;21(1):95-102.

Tolerability and Feasibility of Beta-Blocker Titration in HFpEF Versus HFrEF: Insights From the CIBIS-ELD Trial.
Edelmann F, Musial-Bright L, Gelbrich G, Trippel T, Radenovic S, Wachter R, Inkrot S, Loncar G, Tahirovic E, Celic V, Veskovic J, Zdravkovic M, Lainscak M, Apostolović S, Neskovic AN, Pieske B, Düngen HD.
JACC Heart Fail. 2016 Feb;4(2):140-9.

Should procalcitonin be measured routinely in acute decompensated heart failure?
Loncar G, Tscholl V, Tahirovic E, Sekularac N, Marx A, Obradovic D, Veskovic J, Lainscak M, von Haehling S, Edelmann F, Arandjelovic A, Apostolovic S, Stanojevic D, Pieske B, Trippel T, Dungen HD.
Biomark Med. 2015;9(7):651-9.

Heart rate following short-term beta-blocker titration predicts all-cause mortality in elderly chronic heart failure patients: insights from the CIBIS-ELD trial.
Düngen HD, Musial-Bright L, Inkrot S, Apostolović S, Edelmann F, Lainščak M, Sekularac N, Störk S, Tahirovic E, Tscholl V, Krackhardt F, Loncar G, Trippel TD, Gelbrich G.
Eur J Heart Fail. 2014 Aug;16(8):907-14.

Self-rated health predicts adverse events during β-blocker treatment: the CIBIS-ELD randomised trial analysis.
Lainscak M, Farkas J, Inkrot S, Gelbrich G, Neskovic AN, Rau T, Tahirovic E, Töpper A, Apostolovic S, Haverkamp W, Herrmann-Lingen C, Anker SD, Düngen HD.
Int J Cardiol. 2013 Feb 10;163(1):87-92.

Impact of the β1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients.
Rau T, Düngen HD, Edelmann F, Waagstein F, Lainščak M, Dimković S, Apostolović S, Nešković AN, Haverkamp W, Gelbrich G, Eschenhagen T.
Clin Pharmacol Ther. 2012 Jul;92(1):21-8.